GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs477692 | 1 | rs531572 | chr10:131427569 | MGMT | chr10:131265454-131565783:+ | -0.25 | -5.45 | 9.02E-8 | Response to temozolomide |
| BLCA | cis | rs1077514 | 1 | rs534417 | chr1:23784965 | ASAP3 | chr1:23755056-23811057:- | 0.31 | 4.34 | 1.83E-5 | Cholesterol, total |
| BLCA | cis | rs1077514 | 1 | rs534417 | chr1:23784965 | TCEA3 | chr1:23707555-23751261:- | 0.32 | 4.37 | 1.6E-5 | Cholesterol, total |
| BLCA | cis | rs477692 | 1 | rs538969 | chr10:131410608 | MGMT | chr10:131265454-131565783:+ | 0.21 | 4.57 | 6.58E-6 | Response to temozolomide |
| BLCA | cis | rs548181 | 1 | rs548181 | chr11:125461709 | DDX25 | chr11:125774272-125793003:+ | -0.29 | -3.83 | 0.000148 | Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined);Schizophrenia |
| BLCA | cis | rs477692 | 1 | rs548390 | chr10:131417427 | MGMT | chr10:131265454-131565783:+ | 0.21 | 4.5 | 8.86E-6 | Response to temozolomide |
| BLCA | cis | rs477692 | 1 | rs553371 | chr10:131413676 | MGMT | chr10:131265454-131565783:+ | 0.21 | 4.66 | 4.36E-6 | Response to temozolomide |
| BLCA | cis | rs477692 | 1 | rs554792 | chr10:131423181 | MGMT | chr10:131265454-131565783:+ | 0.22 | 4.88 | 1.57E-6 | Response to temozolomide |
| BLCA | cis | rs732528 | 1 | rs55752096 | chr18:48368918 | MRO | chr18:48321491-48351754:- | 0.26 | 4.63 | 5.09E-6 | Entorhinal cortical thickness |
| BLCA | cis | rs60843830 | 1 | rs55753056 | chr2:243929 | SH3YL1 | chr2:218138-264810:- | -0.44 | -11.65 | 4.86E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs9475752 | 1 | rs55786720 | chr6:56783647 | BEND6 | chr6:56819773-56892138:+ | -0.29 | -4.06 | 6.01E-5 | Menarche (age at onset) |
| BLCA | cis | rs4372836 | 1 | rs55835850 | chr2:28949296 | TRMT61B | chr2:29072690-29093175:- | 0.29 | 5.05 | 6.75E-7 | Body mass index |
| BLCA | cis | rs477692 | 1 | rs558764 | chr10:131426957 | MGMT | chr10:131265454-131565783:+ | -0.21 | -4.46 | 1.09E-5 | Response to temozolomide |
| BLCA | cis | rs55883249 | 1 | rs55883249 | chr2:9741535 | ADAM17 | chr2:9629413-9695917:- | -0.19 | -3.98 | 8.35E-5 | 3-hydroxy-1-methylpropylmercapturic acid levels in smokers |
| BLCA | cis | rs2243480 | 1 | rs55895244 | chr7:65387678 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 4.39 | 1.48E-5 | Diabetic kidney disease |